PXD053257-1

PXD053257 is an original dataset announced via ProteomeXchange.

Title	Human stool (IBD patients, LC-MS/MS)
Description	Fecal samples (n=52) of a cohort of IBD patients were collected before and after 14 weeks of treatment with three different biologics. Clinical disease activity scores were used to determine the clinical response and remission. Fecal metaproteomes of remitting patients (n=12) and of non-remitting patients (n=12) were compared before treatment and changes within both groups were assessed over sampling time to identify functional changes and potential human and microbial biomarkers. (2 patients were excluded from finala analyses as the started the therapy in a remitting disease state.)
HostingRepository	PRIDE
AnnounceDate	2026-03-21
AnnouncementXML	Submission_2026-03-21_11:30:25.199.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maximilian Wolf
SpeciesList	scientific name: human gut metagenome; NCBI TaxID: NEWT:408170;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-20 11:49:24	ID requested
⏵ 1	2026-03-21 11:30:26	announced

Wolf M, Lange J, Benndorf D, Welz L, Nikolaus S, Siever LK, Tran F, Schallert K, Hellwig P, Schreiber S, Gunzer M, Rosenstiel P, Reichl U, Adolph T, Jukic A, Aden K, Heyer R, Fecal metaproteomics enables functional characterization of remission in patients with inflammatory bowel disease. J Proteomics, 318():105455(2025) [pubmed]

10.1016/j.jprot.2025.105455;

submitter keyword: Human, IBD, Stool, LC-MS/MS

Prof. Dr. Robert Heyer
contact affiliation	ISAS e.V. Bunsen-Kirchhoff-Straße 11 44139 Dortmund, Germany
contact email	robert.heyer@isas.de
lab head
Maximilian Wolf
contact affiliation	Multidimensional Omics Analyses group, Faculty of Technology, Bielefeld University, Bielefeld, Germany
contact email	maximilian.wolf@uni-bielefeld.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD053257

PRIDE project URI

• PRIDE
  1. PXD053257
     1. Label: PRIDE project
     2. Name: Human stool (IBD patients, LC-MS/MS)