PXD053231-1

PXD053231 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Serum Proteomics Reveals Survival-Associated Biomarkers in Pancreatic Cancer Patients Treated with Chemoimmunotherapy
Description	Immunotherapy has transformed the landscape of cancer treatment but remains largely ineffective for patients with pancreatic ductal adenocarcinoma (PDAC). Some patients, however, show improved outcomes when treated with a combination of immunotherapy and chemotherapy. Here, we conducted deep serum proteome analysis to investigate the protein profiles of PDAC patients and changes during this combinatorial treatment. Utilizing an advanced serum workflow, we quantified 1,011 proteins across 211 samples from 62 patients. Glycolytic enzymes were associated with survival in anti-PD-1 treated patients, with their abundances significantly correlating with expression levels in tumor biopsies. Notably, a set of protein biomarkers was found to be highly predictive of survival in anti-PD-1-treated patients (AUC = 0.91). Overall, our data demonstrate the potential of deep serum proteomics for precision medicine, offering a powerful tool to guide patient selection for treatment through minimally invasive serum protein biomarker measurements.
HostingRepository	MassIVE
AnnounceDate	2025-03-07
AnnouncementXML	Submission_2025-03-07_00:18:59.688.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roland Bruderer
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl; Oxidation; Deamidated:18O(1)
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-19 02:51:43	ID requested
⏵ 1	2025-03-07 00:19:00	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: plasma, cancer, biomarker, immunotherapy, chemotherapy, pancreatic ductal adenocarcinoma

submitter keyword: plasma, cancer, biomarker, immunotherapy, chemotherapy, pancreatic ductal adenocarcinoma

Contact List

Christoph B. Messner
contact affiliation	Swiss Institute of Bioinformatics (SIB), 1005 Lausanne
contact email	christoph.messner@siaf.uzh.ch
lab head
Roland Bruderer
contact affiliation	Biognosys AG
contact email	roland.bruderer@biognosys.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095077/