PXD053223-1

PXD053223 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A transphyletic study of metazoan β-catenin protein complexes
Description	β-catenin plays a vital role in various biological processes, such as body axis determination and cell differentiation, during embryonic development in metazoans. These β-catenin functions are thought to be exerted through complexes formed with various types of proteins. Although β-catenin complex proteins have been identified in several bilaterian models, little is known about the structural and functional properties of β-catenin complexes in the early metazoan evolutionary phases. In this study, we performed a comparative analysis of β-catenin sequences in nonbilaterian lineages that branched off early in metazoan evolution. We aslo carried out a transphyletic function experiments of β-catenin from non-bilaterian metazoans using developing Xenopus embryos, which included secondary axis induction in embryos and proteomic analysis of the β-catenin protein complex. Comparative functional analysis of nonbilaterian β-catenins also demonstrated sequence characteristics important for β-catenin function, and the deep origin and evolutionary conservation of the cadherin-catenin complex. Proteins coimmunoprecipitated with β-catenin included several proteins conserved across metazoans. These data provide a new insight into the conserved repertoire of β-catenin complexes.
HostingRepository	jPOST
AnnounceDate	2025-01-21
AnnouncementXML	Submission_2025-01-20_20:49:43.055.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chihiro Kawano
SpeciesList	scientific name: cellular organisms; NCBI TaxID: 131567;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; alpha-amino acetylated residue
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-18 22:32:51	ID requested
⏵ 1	2025-01-20 20:49:43	announced

Publication List

Mbogo I, Kawano C, Nakamura R, Tsuchiya Y, Villar-Briones A, Hirao Y, Yasuoka Y, Hayakawa E, Tomii K, Watanabe H, -catenin protein complexes. Zoological Lett, 10(1):20(2024) [pubmed]

Mbogo I, Kawano C, Nakamura R, Tsuchiya Y, Villar-Briones A, Hirao Y, Yasuoka Y, Hayakawa E, Tomii K, Watanabe H, -catenin protein complexes. Zoological Lett, 10(1):20(2024) [pubmed]

Keyword List

submitter keyword: β-catenin, metazoan, Nematostella vectensis, proteomics, protein complex

submitter keyword: β-catenin, metazoan, Nematostella vectensis, proteomics, protein complex

Contact List

Hiroshi Watanabe
lab head
Chihiro Kawano
contact affiliation	OIST
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003178/