PXD053221-1
PXD053221 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Neddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway |
| Description | Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational modification involved in the mitochondria function, was upregulated in liver biopsies from APAP-induced liver injury (AILI) patients and in mice treated with an APAP overdose. MLN4924, an inhibitor of the NEDD8 activating enzyme (NAE-1), ameliorated necrosis and boost liver regeneration in AILI. To understand how neddylation interferes in AILI, whole-body biotinylated NEDD8 (bioNEDD8) and Ubiquitin (bioUB) transgenic mice were investigated under APAP overdose with and without MLN4924. The CDP-DAG synthase TAM41, responsible to produce cardiolipin essential for mitochondrial activity, was found modulated under AILI and restoring its levels by inhibiting neddylation. Understanding this ubiquitin-like crosstalk in AILI is essential for developing promising targeted inhibitors for DILI treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-18 |
| AnnouncementXML | Submission_2024-06-18_22:00:59.006.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | MAzkargorta |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-18 21:58:00 | ID requested | |
| ⏵ 1 | 2024-06-18 22:00:59 | announced | |
| 2 | 2024-12-12 19:07:18 | announced | 2024-12-13: Update information. |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: APAP, AILI, NAE1, NEDD8 |
Contact List
| Felix Elortza | |
|---|---|
| contact affiliation | Center for Cooperative Research in Biosciences (CIC bioGUNEļ¼ |
| contact email | felortza@cicbogune.es |
| lab head | |
| MAzkargorta | |
| contact affiliation | Center for Cooperative Research in Biosciences (CIC bioGUNEļ¼ |
| contact email | mazkargorta@cicbiogune.es |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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