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PXD053215-1

PXD053215 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Evolocumab as an immunomodulator in glioma: A window of opportunity trial evaluating PCSK9 inhibition to enhance surface MHC-I on tumor
Description	Many cancers, including glioma, evade immunosurveillance by downregulating major histocompatibility class (MHC)-I expression. Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes intracellular degradation of multiple receptors, including MHC-I. Inhibition of PCSK9 (PCSK9i) blocks MHC-I degradation and potentiates immune checkpoint blockade (ICB) against multiple cancers in vivo. Evolocumab is an FDA approved PCSK9i monoclonal antibody (mAb) indicated for hyperlipidemia. However, mAbs have limited penetrance across the blood brain/tumor barrier (BBB/BTB). We therefore conducted a non-randomized surgical window-of-opportunity study to evaluate if pre-operative subcutaneous (SC) Evolocumab penetrates the blood-brain/tumor barrier to reach tumor and exert a biological effect (PesKE; NCT04937413). Four patients received pre-procedure evolocumab and had sufficient tissue for research, while 17 were analyzed as contemporaneous controls. Evolocumab was quantified in whole blood and tumor across by mass spectroscopy (LC-MS/MS).
HostingRepository	PanoramaPublic
AnnounceDate	2025-09-21
AnnouncementXML	Submission_2025-09-21_16:49:34.841.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Matt Foster
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Label:13C(6)15N(2); Label:13C(6)15N(4)
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-18 15:26:52	ID requested
⏵ 1	2025-09-21 16:49:35	announced

Publication List

no publication

Keyword List

submitter keyword: glioma, biotherapeutic, whole blood, tumor

Contact List

Matt Foster
contact affiliation	Duke Proteomics and Metabolomics Core Facility
contact email	mwfoster@duke.edu
lab head
Matt Foster
contact affiliation	Duke Proteomics and Metabolomics Core Facility
contact email	mwfoster@duke.edu
dataset submitter

Full Dataset Link List

Panorama Public dataset URI