PXD053178-1
PXD053178 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Title: Site specific O-GlcNAcylation of progesterone receptor (PR) supports PR attenuation of interferon stimulated genes (ISGs) and tumor growth in breast cancer |
Description | Hormone receptor (HR) positive breast cancer, defined by expression of estrogen (ER) and/or progesterone (PR) receptor expression, is the most commonly diagnosed type of breast cancer. PR alters the transcriptional landscape to support tumor growth in concert with or independent of ER. Understanding the mechanisms regulating PR function are critical to developing new strategies to treat HR+ breast cancer. O-GlcNAc is a post-translational modification responsible for nutrient sensing that fine tunes protein function. We have previously reported O-GlcNAcylation on PR. Although PR is heavily post translationally modified, primarily through phosphorylation, specific sites of O-GlcNAcylation on PR, and how they regulate PR action, have not been investigated. Using established PR-expressing breast cancer cell lines, we mapped the sites of O-GlcNAcylation on PR. RNA-sequencing revealed site-specific O-GlcNAcylation of PR is critical for ligand-independent suppression of interferon signaling, a regulatory function of PR previously studied in our lab. Furthermore, O-GlcNAcylation of PR enhances PR-driven tumor growth in vivo. We have delineated one mechanism regulating PR function in breast cancer that impacts tumor growth, and provided additional insight into the mechanism through which PR attenuates interferon signaling. |
HostingRepository | MassIVE |
AnnounceDate | 2024-10-25 |
AnnouncementXML | Submission_2024-10-25_08:22:17.151.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Antonio Artigues |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
ModificationList | unknown modification |
Instrument | instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-06-17 15:09:12 | ID requested | |
⏵ 1 | 2024-10-25 08:22:17 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Breeast canter, proteomics, OGlcNAc |
Contact List
Chrity Hagan | |
---|---|
contact affiliation | University of Kansas Medical Center |
contact email | chagan@kumc.edu |
lab head | |
Chad Slawson | |
contact affiliation | University of Kansas Medical Center |
contact email | cslawson@kumc.edu |
lab head | |
Antonio Artigues | |
contact affiliation | University of Kansas Medical Center |
contact email | aartigues@kumc.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095057/ |