PXD053107 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Disruption of Glucose Homeostasis in Prey: Combinatorial Use of Weaponized Mimetics of Somatostatin and Insulin by a Fish-Hunting Cone Snail |
Description | Venomous animals have evolved diverse molecular mechanisms to incapacitate prey and defend against predators. The majority of venom components characterized to date disrupt the nervous, locomotor, and cardiovascular system or causes tissue damage and degradation1. The discovery that certain species of fish-hunting cone snail use weaponized insulins to induce hypoglycemic shock in prey provided an unusual example for the use of toxins that target glucose homeostasis2. Here, we show that, in addition to insulins, the deadly fish hunter, Conus geographus, uses a selective agonist of the somatostatin receptor 2 (SSTR2) that potently blocks the release of the insulin-counteracting hormone glucagon, thereby exacerbating insulin-induced hypoglycemia in prey. The native toxin, Consomatin nG1, exists in several proteoforms that contain a minimized vertebrate somatostatin-like core motif connected to a heavily glycosylated N-terminal region. We demonstrate that the toxin’s N-terminal tail aligns with a glycosylated somatostatin peptide previously identified from fish pancreas and plays an important role in activating the fish SSTR2. Collectively, these findings provide a stunning example of chemical mimicry, highlight the combinatorial nature of venom components, and establish glucose homeostasis as an effective target for prey capture. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-26 |
AnnouncementXML | Submission_2024-06-26_08:18:37.933.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD053107 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Thomas Koch |
SpeciesList | scientific name: Conus geographus (Geography cone) (Nubecula geographus); NCBI TaxID: 6491; |
ModificationList | amidated residue; 2-pyrrolidone-5-carboxylic acid (Gln); monohydroxylated residue; O-glycosyl-L-threonine |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-14 03:24:12 | ID requested | |
⏵ 1 | 2024-06-26 08:18:38 | announced | |
Publication List
Keyword List
submitter keyword: cabals, glycosylation, somatostatin, weaponized hormones, venom, chemical mimicry, glycopeptides, doppelganger peptide, toxins, cone snail, glucose homeostasis, insulin |
Contact List
Helena Safavi-Hemami |
contact affiliation | Department of Biochemistry, University of Utah |
contact email | helena.safavi@biochem.utah.edu |
lab head | |
Thomas Koch |
contact affiliation | University of Utah |
contact email | thomas.lund.koch@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053107
- Label: PRIDE project
- Name: Disruption of Glucose Homeostasis in Prey: Combinatorial Use of Weaponized Mimetics of Somatostatin and Insulin by a Fish-Hunting Cone Snail