PXD053074-1

PXD053074 is an original dataset announced via ProteomeXchange.

Title	LC-MSMS in axenically cultured C. elegans
Description	Dietary restriction (DR) is a well-established method for extending lifespan across various species, including C. elegans. Among the different DR regimens, axenic dietary restriction (ADR), in which worms are grown in a nutrient-rich sterile liquid medium, yields the most powerful lifespan extension. However, the molecular mechanisms underlying this longevity phenotype remain largely unexplored. Through a pilot screen of candidate genes, we identified the proprotein convertase BLI-4 as a crucial factor in neurons for modulating lifespan under ADR conditions. BLI-4's role appears to be specific to ADR, as it does not significantly impact longevity under other DR regimens.
HostingRepository	PRIDE
AnnounceDate	2025-07-21
AnnouncementXML	Submission_2025-07-20_16:11:48.992.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ping Wu
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-13 04:38:06	ID requested
⏵ 1	2025-07-20 16:11:49	announced

10.1111/acel.70058;

Wu P, Vandemeulebroucke L, Cai H, Braeckman BP, The Proprotein Convertase BLI-4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans. Aging Cell, 24(7):e70058(2025) [pubmed]

submitter keyword: C. elegans, dieatry restriction

Bart P.Braeckman
contact affiliation	Laboratory of Aging Physiology and Molecular Evolution, Biology Department,Ghent University.
contact email	bart.braeckman@ugent.be
lab head
Ping Wu
contact affiliation	Ghent university
contact email	pingwuscut@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD053074

PRIDE project URI

• PRIDE
  1. PXD053074
     1. Label: PRIDE project
     2. Name: LC-MSMS in axenically cultured C. elegans