PXD053061 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance |
Description | Obesity impairs tissue insulin sensitivity and signaling, promoting type-2 diabetes. Although improving insulin signaling is key to reversing diabetes, the multi-organ mechanisms regulating this process are poorly defined. We screened the secretome and receptome in Drosophila to identify the hormonal crosstalk affecting diet-induced insulin resistance and obesity. We discovered a complex interplay between muscle, neuronal, and adipose tissues, mediated by Bone Morphogenetic Protein (BMP) signaling and the hormone Bursicon, that enhances insulin signaling and sugar tolerance. Muscle-derived BMP signaling, induced by sugar, governs neuronal Bursicon signaling. Bursicon, through its receptor Rickets, a Leucine-rich-repeat-containing G-protein coupled receptor (LGR), improves insulin secretion and insulin sensitivity in adipose tissue, mitigating hyperglycemia. In mouse adipocytes, loss of the Rickets ortholog LGR4 blunts insulin responses, showing an essential role of LGR4 in adipocyte insulin sensitivity. Our findings reveal a muscle-neuronal-fat-tissue axis driving metabolic adaptation to high-sugar conditions, identifying LGR4 as a critical mediator in this regulatory network. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-27 |
AnnouncementXML | Submission_2024-06-27_09:22:58.819.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Martin R. Larsen |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | phosphorylated residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-06-12 23:40:14 | ID requested | |
⏵ 1 | 2024-06-27 09:22:59 | announced | |
2 | 2024-10-22 06:47:45 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Phosphoproteomics, Muscle-adipose tissue crosstalk, LGR,Insulin resistance, T2D |
Contact List
Kim Rewitz |
contact affiliation | Department of Biology, University of Copenhagen, 2100 Copenhagen O, Denmark |
contact email | Kim.Rewitz@bio.ku.dk |
lab head | |
Martin R. Larsen |
contact affiliation | University of Southern Denmark |
contact email | mrl@bmb.sdu.dk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD053061
- Label: PRIDE project
- Name: LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance