PXD053050-1

PXD053050 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Integrated multi-omics assessment of lineage plasticity features in a prostate cancer patient with brain and dural metastases
Description	Metastasis to the brain is rare in prostate cancer and unfortunately, incredibly lethal. We evaluated the tissue biopsies of a patient with a treatment-induced metastatic lesion to the brain of the neuroendocrine prostate cancer (NEPC) subtype. We performed genomic, transcriptomic, and proteomic characterization on the primary prostate tumor, the metastatic brain NEPC, and an additional metastatic nodule in the dura with adenocarcinoma histology. These data are the proteomics result of this patient, with three replicates for each sample (primary prostate, dura adenocarcinoma, brain NEPC).
HostingRepository	MassIVE
AnnounceDate	2024-09-30
AnnouncementXML	Submission_2024-09-30_07:49:28.264.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Megan Ludwig
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	Orbitrap Eclipse

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-12 12:13:53	ID requested
⏵ 1	2024-09-30 07:49:28	announced

Publication List

Megan L. Ludwig, David Moline, Alec Horrmann, Ella Boytim, Gabrianne Larson, Ali T. Arafa, Masooma Sayeda, John R. Lozada, Hannah E. Bergom, Abderrahman Day, Sandhyarani Dasaraju, Scott M. Dehm, Paari Murugan, Justin Hwang, Justin M. Drake & Emmanuel S. Antonarakis. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. Ludwig, M.L., Moline, D., Horrmann, A. et al. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. npj Precis. Onc. 8, 215 (2024). https://doi.org/10.1038/s41698-024-00713-8.

Megan L. Ludwig, David Moline, Alec Horrmann, Ella Boytim, Gabrianne Larson, Ali T. Arafa, Masooma Sayeda, John R. Lozada, Hannah E. Bergom, Abderrahman Day, Sandhyarani Dasaraju, Scott M. Dehm, Paari Murugan, Justin Hwang, Justin M. Drake & Emmanuel S. Antonarakis. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. Ludwig, M.L., Moline, D., Horrmann, A. et al. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. npj Precis. Onc. 8, 215 (2024). https://doi.org/10.1038/s41698-024-00713-8.

Keyword List

submitter keyword: Proteomics, Prostate Cancer, Neuroendocrine, Adenocarcinoma, Biopsy Tissue, Brain Metastasis, Case Report

submitter keyword: Proteomics, Prostate Cancer, Neuroendocrine, Adenocarcinoma, Biopsy Tissue, Brain Metastasis, Case Report

Contact List

Justin M. Drake PhD
contact affiliation	University Minnesota
contact email	jdrake@umn.edu
lab head
Megan Ludwig
contact affiliation	University of Minnesota
contact email	mlludwig@umn.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095007/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v08/MSV000095007/