PXD052994-1

PXD052994 is an original dataset announced via ProteomeXchange.

Title	Tear Proteomics Analysis in Children and Adolescents with Type 1 Diabetes
Description	Fifty-six children and adolescents with type 1 diabetes at least one year after diagnosis, aged 6-17 years old and fifty-six healthy age- and sex-matched subjects were enrolled in this cross-sectional study. Tear samples were collected using Schirmer strips placed on the lower eyelid. The proteomic analysis was based on a detergent-assisted protein extraction and their digestion from the tears, analysis of the tryptic peptides with LC-MS/ enabling the identification, and quantification of the Shirmer strip protein content via DIA-NN, and subsequently the statistical and bioinformatic analysis using the R and Metascape enrichment analysis tool.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_06:04:20.528.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Martina Samiotaki
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-10 23:02:00	ID requested
⏵ 1	2024-10-17 06:04:21	announced

10.3390/ijms25189994;

Angelopoulou E, Kitani RA, Stroggilos R, Lygirou V, Vasilakis IA, Letsou K, Vlahou A, Zoidakis J, Samiotaki M, Kanaka-Gantenbein C, Nicolaides NC, Tear Proteomics in Children and Adolescents with Type 1 Diabetes: A Promising Approach to Biomarker Identification of Diabetes Pathogenesis and Complications. Int J Mol Sci, 25(18):(2024) [pubmed]

submitter keyword: diabetic complications, mass spectrometry,biomarkers, children, glycemic control, tear proteome, diabetic ketoacidosis, type 1 diabetes

Nicolas C. Nicolaides
contact affiliation	Diabetes Center, Division of Endocrinology, Diabetes and Metabolism, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, “Aghia Sophia” Children’s Hospital, Athens, Greece
contact email	nnicolaides@bioacademy.gr
lab head
Martina Samiotaki
contact affiliation	Protein Analysis Laboratory B.S.R.C. "Alexander Fleming", Alexander Fleming Street 34 16672, Vari, Greece
contact email	samiotaki@fleming.gr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD052994

PRIDE project URI

• PRIDE
  1. PXD052994
     1. Label: PRIDE project
     2. Name: Tear Proteomics Analysis in Children and Adolescents with Type 1 Diabetes