PXD052986-1
PXD052986 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The proteomics analysis of Chimeric exosomes |
| Description | Immunotherapy is a breakthrough in the treatment of triple-negative breast cancer (TNBC), whereas is effective in a portion of patients. Our clinical studies found that lipid homeostasis imbalance and dendritic cells (DCs) dysfunction contributed to the immunosuppressive microenvironment in the lymph nodes (LNs) of TNBC patients following immunotherapy, which greatly affected the immunotherapeutic efficacy. Building on this, we introduce a chimeric exosomes-derived immunomodulator, EMV@SS-Toy, involving a polysulfide bond-bridged mesoporous silica nanoparticles (SS-MSN) as a reactive oxygen species (ROS) scavenger and responsive carrier nucleus, loading with the (IRE1α-XBP1) inhibitor toyocamycin (Toy) and coating with chimeric exosomes comprising DCs-derived exosomes and Salmonella outer membrane vesicles. This multifaceted immunomodulator can significantly enhance LNs’ homing via homologous targeting and chemokine-guided navigation, enabling a pathological ROS-responsive drug release, dual-stress pathway regulation, thereby restoring and DCs’ function and LNs’ immune microenvironment. As expected, the immunomodulator markedly boosted the responsiveness of TNBC to immunotherapy, exerting potent inhibition on both the primary tumor and metastases and establishing long-term immune surveillance. Our study provides potent directions for translational immunotherapy through optimizing the LNs’ microenvironment in TNBC. |
| HostingRepository | iProX |
| AnnounceDate | 2024-06-10 |
| AnnouncementXML | Submission_2024-07-31_19:42:05.822.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuxia Wu |
| SpeciesList | scientific name: Mus |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-10 21:14:54 | ID requested | |
| ⏵ 1 | 2024-07-31 19:42:06 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Chimeric exosomes, PAMPs, dendritic cell-derived exosome |
Contact List
| Qiuhua Luo | |
|---|---|
| contact affiliation | The First Hospital of China Medical University |
| contact email | qhluo@cmu.edu.cn |
| lab head | |
| Yuxia Wu | |
| contact affiliation | The First Hospital of China Medical University |
| contact email | wuyuxia1999@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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