PXD052894-1

PXD052894 is an original dataset announced via ProteomeXchange.

Title	Adipocyte autophagy-mediated signals in the control of macrophage phenotype during diet-induced obesity
Description	A hallmark of obesity is a pathological expansion of white adipose tissue that is accompanied by an increase in local inflammation and fibrosis. Autophagy is increased during obesity in adipose tissue, however, its role remains incompletely understood. Here, we report that autophagy is a critical regulator of pathological white adipose tissue remodelling and inflammation in diet-induced obese mice. The absence of adipocyte autophagy substantially exacerbates pericellular fibrosis specifically in gonadal white adipose tissue, ameliorating metabolic syndrome. Notably, changes in tissue architecture correlate with increased infiltration of macrophages and autophagy-dependent rewiring of adipocyte metabolism.
HostingRepository	PRIDE
AnnounceDate	2025-09-26
AnnouncementXML	Submission_2025-09-26_02:25:46.862.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Oliver Popp
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-06 03:11:14	ID requested
⏵ 1	2025-09-26 02:25:47	announced

10.1038/S41467-025-64266-5;

submitter keyword: macrophage,autophagy, adipocyte, white adipose tissue, fibrosis, diabetes and obesity, nucleotide

Katja Simon
contact affiliation	Max Delbrück Center for Molecular Medicine in the Helmholtz Association
contact email	katja.simon@mdc-berlin.de
lab head
Oliver Popp
contact affiliation	MDC Berlin
contact email	oliver.popp@mdc-berlin.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD052894

PRIDE project URI

• PRIDE
  1. PXD052894
     1. Label: PRIDE project
     2. Name: Adipocyte autophagy-mediated signals in the control of macrophage phenotype during diet-induced obesity