PXD052848-1
PXD052848 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Alternatively spliced mini exon B in PTPRD regulates hippocampal excitatory synapses through trans synaptic PTPRD IL1RAP interaction |
| Description | PTPRD is a presynaptic adhesion molecule implicated in various neurological, psychiatric, and neurodevelopmental disorders, but the underlying mechanisms remain unclear. PTPRD trans synaptically interacts with multiple postsynaptic adhesion molecules, thorough the regulation by its extracellular alternatively spliced mini exons (meA and meB). While PTPRD meA regulates specific hippocampal excitatory synapses, PTPRD meB has not been studied in vivo. Here we found that homozygous PTPRD meB mutant (Ptprd meB homo del) mice show early postnatal lethality and that heterozygous Ptprd meB hetero del mice show behavioral and synaptic abnormalities, which are not observed in PTPRD meA mutant mice. In Ptprd-meB hetero del mice, excitatory synapses in dentate gyrus granule cells (DG GCs) show decreased density and transmission, whereas PTPRD meA mutant mice show normal excitatory synaptic transmission. Proteomic analyses indicate decreased postsynaptic levels of IL1RAP, a known trans synaptic partner of PTPRD meB. Accordingly, IL1RAP mutant mice show similarly decreased excitatory synaptic transmission in DG GCs. Therefore, PTPRD meB is more important than PTPRD meA for postnatal survival, excitatory synaptic function, and mouse behaviors, and IL1RAP mediates PTPRD meB dependent excitatory synaptic regulation. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-03-31 |
| AnnouncementXML | Submission_2025-03-31_18:43:18.697.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Yeji Yang |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Carbamidomethyl; Oxidation |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-06-04 22:21:22 | ID requested | |
| ⏵ 1 | 2025-03-31 18:43:19 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Proteomics, PTPRD, hippocampal excitatory synapses, presynaptic adhesion molecule, neurodevelopmental disorders |
Contact List
| Jin Young Kim | |
|---|---|
| contact affiliation | Korea Basic Science Institute |
| contact email | jinyoung@kbsi.re.kr |
| lab head | |
| Yeji Yang | |
| contact affiliation | Korea Basic Science Institute |
| contact email | yangyj@kbsi.re.kr |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v08/MSV000094934/ |
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