PXD052783-1

PXD052783 is an original dataset announced via ProteomeXchange.

Title	Chemotherapy-mediated induction of PD-L1 via SEI1 facilitates myeloma immune evasion
Description	Multiple myeloma (MM) is a malignant neoplasm originating in the plasma cell system, with a higher incidence in elderly individuals. While immune checkpoint blockade-based tumor immunotherapy has shown promising advancements in myeloma treatment, conventional chemotherapy remains the primary therapeutic modality. It remains unclear whether chemotherapy influences the expression of immune checkpoints in myeloma, thus impacting the therapeutic efficacy of checkpoint-related antibodies. In this study, we found that treatment of myeloma cells with chemotherapy drugs such as melphalan or bortezomib induces DNA damage and activates the cGAS/STING signaling pathway. This activation promotes the phosphorylation of the transcription factor IRF7, which then binds to the promoter region of SEI1 gene to enhance its transcription. The SEI1 protein directly interacts with the enhancer factors CBP/p300 and RNA polymerase II (pol II)-associated PAF1 complex, promoting transcriptional activity and leading to the upregulation of PD-L1 expression and causing immune escape in myeloma. These findings not only provide valuable insights for enhancing the therapeutic efficacy of chemotherapy in myeloma but also reveal a novel regulatory mechanism for PD-L1.
HostingRepository	PRIDE
AnnounceDate	2025-05-26
AnnouncementXML	Submission_2025-05-25_16:05:55.440.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	rui chen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	6410 Triple Quadrupole LC/MS

Revision	Datetime	Status	ChangeLog Entry
0	2024-06-02 19:56:51	ID requested
⏵ 1	2025-05-25 16:05:56	announced

10.1002/advs.202411082;

Chen R, Li Z, Fang Z, Li Z, Yang D, Li Y, Liu S, Liu Z, Liu R, Liu H, Chemotherapy-Mediated Induction of PD-L1 via SEI1 Facilitates Myeloma Immune Evasion. Adv Sci (Weinh), 12(19):e2411082(2025) [pubmed]

submitter keyword: Human

Chen Rui
contact affiliation	Cancer Research Center, School of Medicine, Xiamen University
contact email	569386031@qq.com
lab head
rui chen
contact affiliation	Xiamen University
contact email	569386031@qq.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052783

PRIDE project URI

• PRIDE
  1. PXD052783
     1. Label: PRIDE project
     2. Name: Chemotherapy-mediated induction of PD-L1 via SEI1 facilitates myeloma immune evasion