PXD052766-1

PXD052766 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Conditioned medium from human iPSC-derived mesenchymal progenitors: Effect of extended progenitor cultivation vs. osteogenic pre-differentiation on the medium stimulatory activity
Description	Human induced pluripotent stem cells provide an unlimited, scalable source of youthful tissue progenitors and secretome for regenerative therapies. The aim of our study was to assess the potential of conditioned medium (CM) derived from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate osteogenic differentiation of adult and aged human bone marrow-mesenchymal stromal cells (MSCs). In addition, we evaluated whether extended cultivation or osteogenic pre-differentiation of hiPSC-MPs could enhance the CM stimulatory activity.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_18:06:19.150.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Goran Mitulović
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-31 14:57:19	ID requested
⏵ 1	2025-05-06 18:06:20	announced

Publication List

Marolt Presen D, Goeschl V, Hanetseder D, Ogrin L, Stetco AL, Tansek A, Pozenel L, Bruszel B, Mitulovic G, Oesterreicher J, Zipperle J, Schaedl B, Holnthoner W, Grillari J, Redl H, Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Res Ther, 15(1):434(2024) [pubmed]
10.1186/s13287-024-03960-5;

Marolt Presen D, Goeschl V, Hanetseder D, Ogrin L, Stetco AL, Tansek A, Pozenel L, Bruszel B, Mitulovic G, Oesterreicher J, Zipperle J, Schaedl B, Holnthoner W, Grillari J, Redl H, Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Res Ther, 15(1):434(2024) [pubmed]

10.1186/s13287-024-03960-5;

Keyword List

submitter keyword: human iPSCs, osteogenic differentiation, mesenchymal progenitors, proteomic analysis,Conditioned medium, human bone marrow mesenchymal stromal cells, secretome, aging

submitter keyword: human iPSCs, osteogenic differentiation, mesenchymal progenitors, proteomic analysis,Conditioned medium, human bone marrow mesenchymal stromal cells, secretome, aging

Contact List

Darja Marolt Presen
contact affiliation	1. Ludwig Boltzmann Institute for Traumatology The research center in cooperation with AUVA, Donaueschingenstrasse 13, 1200 Vienna, Austria 2. Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, 1200 Vienna, Austria
contact email	darja.marolt@trauma.lbg.ac.at
lab head
Goran Mitulović
contact affiliation	Medizinische Universität Wien
contact email	goran.mitulovic@meduniwien.ac.at
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052766

PRIDE project URI

Repository Record List

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