PXD052765-2

PXD052765 is an original dataset announced via ProteomeXchange.

Title	Redox-proteomic analysis of pancreatic β-cells upon glucose stimulation
Description	Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. This is particularly critical in pancreatic β-cells, which are highly metabolically active and play a specialized role in whole organism glucose homeostasis. Glucose stimulation in β-cells triggers signals leading to insulin secretion, including changes in ATP/ADP ratio and intracellular calcium levels. Additionally, lipid metabolism and reactive oxygen species (ROS) signaling are essential for β-cell function and health. We employed IodoTMT isobaric labeling combined with tandem mass spectrometry to elucidate redox signaling pathways in pancreatic β-cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_07:00:08.489.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Barbora Salovska
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	acetylated residue; monohydroxylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-31 13:37:21	ID requested
1	2024-09-30 08:39:45	announced
⏵ 2	2024-10-22 07:00:09	announced	2024-10-22: Updated project metadata.

10.1016/j.metabol.2024.156027;

submitter keyword: iodoTMT,redox proteomics

Blanka Holendova
contact affiliation	Laboratory of Pancreatic Islets Research, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
contact email	blanka.holendova@fgu.cas.cz
lab head
Barbora Salovska
contact affiliation	Yale Cancer Biology Institute
contact email	salovska.b@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD052765

PRIDE project URI

• PRIDE
  1. PXD052765
     1. Label: PRIDE project
     2. Name: Redox-proteomic analysis of pancreatic β-cells upon glucose stimulation