PXD052723 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Human iPSC-derived mononuclear phagocytes restore cognition, neural health, and a subpopulation of hippocampal mossy cells in aging mice |
| Description | Young blood or plasma and young bone marrow improves cognitive function in aged animals, though the cell type responsible for these regenerative effects remains unknown. This study evaluated the potential of induced pluripotent stem cell-derived mononuclear phagocytes (iMPs) as a therapeutic for age-associated cognitive and neural decline. Aging mice receiving intravenous delivery of iMPs for 3 weeks showed significant improvements in hippocampus dependent cognitive tasks and neural health markers, including increased levels of the synaptic transporter VGLUT1 and decreases in both astrogliosis and activated microglia. Proteomics on plasma and single nuclei RNA sequencing of the hippocampus identified several key aging specific pathways. iMP treatment of aging mice was able to reverse the increases in complement and amyloid pathway proteins, restore a lost subpopulation of hippocampal mossycells, and nearly eliminate a population of activated microglia. These findings suggest that iMPs provide a novel individualized therapeutic strategy to target age-related neural decline. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-18 |
| AnnouncementXML | Submission_2025-11-18_03:20:08.745.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sarah Parker |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-30 09:58:26 | ID requested | |
| ⏵ 1 | 2025-11-18 03:20:09 | announced | |
Publication List
| Moser VA, Dimas-Harms LJ, Lipman RM, Inzalaco J, Bell S, Alcantara M, Valenzuela E, Lawless G, Kreimer S, Parker SJ, Goodridge HS, Svendsen CN, Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease. Adv Sci (Weinh), 12(41):e17848(2025) [pubmed] |
| 10.1002/advs.202417848; |
Keyword List
| submitter keyword: neural health, induced pluripotent stem cells, hippocampus, mononuclear phagocytes,Aging, cognitive decline |
Contact List
| Clive Svendsen |
|---|
| contact affiliation | Regenerative Medicine Institute, Department of Biomedical Sciences |
| contact email | clive.svendsen@cshs.org |
| lab head | |
| Sarah Parker |
|---|
| contact affiliation | Cedars-Sinai Medical Center |
| contact email | sarah.parker@cshs.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD052723 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052723
- Label: PRIDE project
- Name: Human iPSC-derived mononuclear phagocytes restore cognition, neural health, and a subpopulation of hippocampal mossy cells in aging mice
