PXD052694-1

PXD052694 is an original dataset announced via ProteomeXchange.

Title	PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity
Description	Proximity labeling-Mass spectrometry for PDZD8-TurboID KI Neuro2a cells
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_18:13:53.330.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052694
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Chulhwan (Sean) Kwak
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	biotinylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-29 20:08:26	ID requested
⏵ 1	2025-05-06 18:13:54	announced

10.1038/s41467-025-58538-3;

Nakamura K, Aoyama-Ishiwatari S, Nagao T, Paaran M, Obara CJ, Sakurai-Saito Y, Johnston J, Du Y, Suga S, Tsuboi M, Nakakido M, Tsumoto K, Kishi Y, Gotoh Y, Kwak C, Rhee HW, Seo JK, Kosako H, Potter C, Carragher B, Lippincott-Schwartz J, Polleux F, Hirabayashi Y, Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering. Nat Commun, 16(1):3401(2025) [pubmed]

10.6019/PXD052694;

ProteomeXchange project tag: Human Brain Proteome Project (HUPO_HBPP) (B/D-HPP), Human Proteome Project, Bioinformatics Infrastructure for Life Sciences (BILS) network (Sweden)

submitter keyword: biotin-modified peptide identification,mouse neuro-2a cultured cell line, PDZD8 CRSPR-Knock-In TurboID (Proximity labeling), Orbitrap, LC-MS/MS

Yusuke Hirabayashi
contact affiliation	Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan Department of Bioengineering, School of Engineering, The University of Tokyo, Tokyo 113-8656, Japan
contact email	hirabayashi@chembio.t.u-tokyo.ac.jp
lab head
Chulhwan (Sean) Kwak
contact affiliation	Stanford university
contact email	seanckwak@stanford.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD052694

PRIDE project URI

• PRIDE
  1. PXD052694
     1. Label: PRIDE project
     2. Name: PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity