PXD052671-1

PXD052671 is an original dataset announced via ProteomeXchange.

Title	The structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator
Description	Zika virus, an arbovirus, relies on mosquitoes as vectors for its spread and transmission. During blood feeding mosquitoes inoculate saliva containing various proteins. Recently, AgBR1, an Aedes aegypti salivary gland protein, has garnered attention for its immunomodulatory viral activity, along with another protein, NeSt1. We have solved the crystal structure of AgBR1, whose chitinase fold has been repurposed, likely to help blood feeding. We show that AgBR1 and NeSt1, when present in murine macrophages, alter functional cellular pathways related to virus entry by endocytosis, immune response, and cell proliferation. AgBR1 (and NeSt1) do not directly bind to the Zika virus or modulate its replication. In this light, we suggest that their immunomodulatory activity on Zika transmission is through the modulation of host-cell response, likely a consequence of evolutionary crosstalk and virus opportunism. Our structural and functional insights are prerequisites for developing strategies to halt the spread of mosquito-borne disease.
HostingRepository	PRIDE
AnnounceDate	2025-04-04
AnnouncementXML	Submission_2025-04-04_06:31:26.750.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-29 04:05:07	ID requested
⏵ 1	2025-04-04 06:31:27	announced

Dataset with its publication pending

submitter keyword: mosquito salivary proteins, immunomodulators,Zika virus

Felix Elortza
contact affiliation	Proteomics Service CICbioGUNE Build. 800 Bizkaia Tech. Park Derio 48160 Spain
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD052671

PRIDE project URI

• PRIDE
  1. PXD052671
     1. Label: PRIDE project
     2. Name: The structural and functional significance of Aedes aegypti AgBR1 flavivirus immunomodulator