PXD052642 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer |
| Description | The assessment of global changes in fibrillar collagens and to the larger extent e.g., ECM induced upon inhibitor treatment has largely been lacking for the currently available LOX family inhibitors. We therefore undertook a quantitative pharmacodynamics approach to characterize the global alterations in the ECM composition and organization upon targeting LOX with LXG6403 using state-of-the-art ECM-targeted proteomics coupled with mass spectrometry imaging |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-01 |
| AnnouncementXML | Submission_2025-11-30_16:53:05.520.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Harrison Taylor |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | acetylated residue; monohydroxylated residue; monohydroxylated proline; deamidated residue |
| Instrument | Bruker Daltonics instrument model |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-28 14:25:36 | ID requested | |
| ⏵ 1 | 2025-11-30 16:53:06 | announced | |
Publication List
| Cetin M, Saatci O, Rezaeian AH, Rao CN, Beneker C, Sreenivas K, Taylor H, Pederson B, Chatzistamou I, Buckley B, Lessner S, Angel P, McInnes C, Sahin O, A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer. Cell Chem Biol, 31(11):1926-1941.e11(2024) [pubmed] |
| 10.1016/j.chembiol.2024.06.012; |
Keyword List
| submitter keyword: LOX inhibitor, collagen architecture, ROS,Lysyl oxidase, FAK, TNBC chemoresistance |
Contact List
| Peggi Angel |
|---|
| contact affiliation | Dept. of Pharmacology Basic Science Building, Rm 306 Medical University of South Carolina United States of America |
| contact email | angelp@musc.edu |
| lab head | |
| Harrison Taylor |
|---|
| contact affiliation | Medical University of South Carolina |
| contact email | taylorha@musc.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD052642 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052642
- Label: PRIDE project
- Name: A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
