PXD052582 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Molecular and functional landscape of malignant serous effusions for precision oncology |
Description | Personalized treatment for patients with advanced solid tumors critically depends on the deep characterization of tumor cells from patient biopsies. Here, we comprehensively characterize a pan-cancer cohort of 150 malignant serous effusion (MSE) samples at the cellular, molecular, and functional level. We find that MSE-derived cancer cells retain the genomic and transcriptomic profiles of their corresponding primary tumors, validating their use as a patient-relevant model system for solid tumor biology. Integrative analyses reveal that baseline gene expression patterns relate to global ex vivo drug sensitivity, while high-throughput drug-induced transcriptional changes in MSE samples are indicative of drug mode of action and acquired treatment resistance. A case study exemplifies the added value of multi-modal MSE profiling for patients who lack genetically stratified treatment options. In summary, our study provides a functional multi-omics view on a pan-cancer solid tumor cohort and underlines the feasibility and utility of MSE-based precision oncology. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-04 |
AnnouncementXML | Submission_2024-10-04_05:30:56.394.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Valentina Cappelletti |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-27 01:48:07 | ID requested | |
⏵ 1 | 2024-10-04 05:30:56 | announced | |
2 | 2024-10-22 07:00:43 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: MSE, cancer, DIA, Human,malignant serous effusion |
Contact List
Paola Picotti |
contact affiliation | Institute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland |
contact email | picotti@imsb.biol.ethz.ch |
lab head | |
Valentina Cappelletti |
contact affiliation | ETH |
contact email | cappelletti@imsb.biol.ethz.ch |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD052582 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052582
- Label: PRIDE project
- Name: Molecular and functional landscape of malignant serous effusions for precision oncology