PXD052573-1

PXD052573 is an original dataset announced via ProteomeXchange.

Title	Functional Optic Tract Rewiring via Subtype- and Target-specific Axonal Regeneration and Presynaptic Activity Enhancement
Description	We showed that with genetic manipulation as Pten/Socs3 knockout (KO), CNTF overexpression and Lipin1 knockdown (PSCL), RGCs could regenerate and reinnervate into OPN nuclei after pre-OPN optic tract injury. We then performed single-cell RNA sequencing on OPN-projecting retinal ganglion cells and proteomic analysis of the OPN regions to investigate the dynamic transcriptomic and proteomic changes during axonal regeneration. We had total 8 groups: GFP-intact, GFP-5dpi (5 days post injury), GFP-1.5mpi (1.5 months post injury), GFP-3mpi, PSCL-intact, PSCL-5dpi, PSCL-1.5mpi, PSCL-3mpi.
HostingRepository	iProX
AnnounceDate	2024-05-25
AnnouncementXML	Submission_2025-11-18_00:20:50.525.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chengle Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-26 22:47:43	ID requested
⏵ 1	2025-11-18 00:20:51	announced

Zhang X, Yang C, Zhang C, Wu J, Zhang X, Gao J, Wang X, Chan LT, Zhou Y, Chen Y, Tam SST, Chen S, Ma Y, Yung WH, Duan L, Jiang L, Wang Y, Liu K, Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement. Nat Commun, 16(1):2174(2025) [pubmed]

submitter keyword: optic tract, axon regeneration, olivary pretectal nucleus

Kai Liu
contact affiliation	Hong Kong University of Science and Technology
contact email	kailiu@ust.hk
lab head
Chengle Zhang
contact affiliation	Hong Kong University of Science and Technology
contact email	czhangca@connect.ust.hk
dataset submitter

iProX dataset URI