PXD052529-1

PXD052529 is an original dataset announced via ProteomeXchange.

Title	Changes in the serum proteome profile of patients with neuroborreliosis, foresters, and patients after ILADS therapy
Description	Objectives: The aim of study was to evaluate the changes in proteomic profile of human serum induced by the development of tick-borne neuroborreliosis (NB), before/after therapy, patients treated with prolonged multidrug therapy according to ILADS (International Lyme and Associated Diseases Society), and foresters frequently exposed to tick bites. Methods: A proteomics approach was used to analyze the expression of proteins in serum of patients and sex/age-matched healthy donors. The analysis was performed using SDS-PAGE/LC-MS/MS (Q-Exactive OrbiTrap mass spectrometer). Results: Obtained results indicated changes in the serum proteome of patients with NB putting attention to the proteins involved mainly in calcium transport/metabolism and signaling molecules that differ patients before and after classic therapy. Moreover, ILADS treated patients have different protein distribution than patients from other groups, what is the consequence of prolonged antibiotic therapy. In the case of foresters, the most important result is the increased β-secretase level, suggesting a soon-developing neurodegenerative disease. Conclusions: Obtained results may contribute to a better understanding of the mechanism of the development of tick-bone diseases, as well as will allow create new opportunities for its rapid and more effective therapy. However, further studies, on larger patients groups, are needed to apply them in clinical practice.
HostingRepository	PRIDE
AnnounceDate	2025-01-18
AnnouncementXML	Submission_2025-01-17_19:52:17.540.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Agnieszka Gęgotek
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-23 12:30:02	ID requested
⏵ 1	2025-01-17 19:52:18	announced

10.1038/s41467-024-51174-3;

Li VL, Xiao S, Schlosser P, Scherer N, Wiggenhorn AL, Spaas J, Tung AS, Karoly ED, K, ö, ttgen A, Long JZ, SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Nat Commun, 15(1):6895(2024) [pubmed]

submitter keyword: neuroborreliosis, foresters

ILADS

proteome;

Agnieszka Gegotek
contact affiliation	UMB, Poland
contact email	agnieszkagegotek@o2.pl
lab head
Agnieszka Gęgotek
contact affiliation	Medical University of Białystok
contact email	agnieszkagegotek@o2.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD052529

PRIDE project URI

• PRIDE
  1. PXD052529
     1. Label: PRIDE project
     2. Name: Changes in the serum proteome profile of patients with neuroborreliosis, foresters, and patients after ILADS therapy