PXD052468 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Genetic Control Over Biogenic Crystal Morphogenesis in Zebrafish |
Description | Organisms had to evolve mechanisms that regulate the properties of biogenic crystals to support a wide range of functions, from vision and camouflage to communication and thermal regulation. Yet, the mechanism underlying the formation of diverse intracellular crystals remains enigmatic. Here, we have unraveled the bio-chemical control over crystal morphogenesis in zebrafish iridophores. We show that the chemical composition of the crystals determines their shape, specifically by the ratio between the nucleobases guanine and hypoxanthine. Moreover, we reveal that these variations in composition are genetically controlled through tissue-specific expression of specialized paralogues, which exhibits remarkable substrate selectivity. This orchestrated combination grants the organism with the capacity to generate a broad spectrum of crystal morphologies. Overall, our findings suggest a new mechanism for the morphological and functional diversity of biogenic crystals and may thus inspire the development of genetically designed biomaterials and medical therapeutics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-07-31 |
AnnouncementXML | Submission_2024-07-31_01:46:21.819.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD052468 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Meital Kupervaser |
SpeciesList | scientific name: Danio rerio (Zebrafish) (Brachydanio rerio); NCBI TaxID: 7955; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Orbitrap Exploris 480 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-22 01:19:05 | ID requested | |
⏵ 1 | 2024-07-31 01:46:22 | announced | |
Publication List
Keyword List
submitter keyword: Guanine,Iridophore, Substrate selectivity, Controlled biosynthesis, Paralogous enzymes, Crystal morphogenesis |
Contact List
Dvir Gur |
contact affiliation | Department of Molecular Genetics, Weizmann Institute of Science; Rehovot, 7610001, Israel |
contact email | dvir.gur@weizmann.ac.il |
lab head | |
Meital Kupervaser |
contact affiliation | Weizmann Institute of Science |
contact email | meital.kupervaser@weizmann.ac.il |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052468
- Label: PRIDE project
- Name: Genetic Control Over Biogenic Crystal Morphogenesis in Zebrafish