PXD052436-2

PXD052436 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Bacterial pore-forming toxin pneumolysin drives pathogenicity through host extracellular vesicles released during infection
Description	In this study, we characterized the proteomic composition of extracellular vesicles released from human THP-1 monocytes challenged with the pneumococcal pore-forming toxin, pneumolysin. We found that the vesicles shed from pneumolysin challenged cells are selectively enriched in key inflammatory host proteins relative to vesicles from untreated cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:52:01.667.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052436
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Karthik Subramanian
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-21 04:39:31	ID requested
1	2024-07-31 07:27:18	announced
⏵ 2	2024-10-22 06:52:02	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/J.ISCI.2024.110589;
10.6019/PXD052436;

10.1016/J.ISCI.2024.110589;

10.6019/PXD052436;

Keyword List

submitter keyword: Human, Monocytes, pneumolysin challenge, inflammation, Streptococcus pneumoniae, LC-MS, exosome cargo

submitter keyword: Human, Monocytes, pneumolysin challenge, inflammation, Streptococcus pneumoniae, LC-MS, exosome cargo

Contact List

Dr Karthik Subramanian
contact affiliation	Scientist C & DBT-Ramalingaswami Faculty Fellow Rajiv Gandhi Centre for Biotechnology Campus 2, Aakkulam, Thiruvananthapuram, Kerala, India
contact email	karthik@rgcb.res.in
lab head
Karthik Subramanian
contact affiliation	Scientist C & DBT-Ramalingaswami Faculty Fellow, Rajiv Gandhi Centre for Biotechnology (RGCB), Campus 2, Aakkulam, Thiruvananthapuram, Kerala
contact email	karthik@rgcb.res.in
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD052436
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/07/PXD052436

PRIDE project URI

Repository Record List

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