PXD052378-2

PXD052378 is an original dataset announced via ProteomeXchange.

Title	Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network
Description	Using affinity purification-mass spectrometry (AP-MS), we identified the novel Mnb binding partners Ral interacting protein (Rlip) and RALBP1 associated Eps domain containing (Reps). Rlip and Reps physically and genetically interact with Mnb, and the three proteins may form a ternary complex. Mnb phosphorylates Reps, and human DYRK1A binds to the Reps orthologs REPS1 and REPS2. Furthermore, Mnb engages the small GTPase Ras-like protein A (Rala) to regulate brain and wing development. This work uncovers a previously unrecognized early role of Mnb in the neuroepithelium and defines the functions of the Mnb/Reps/Rlip/Rala signaling network in brain development.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:57:49.760.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Alexey Veraksa
SpeciesList	scientific name: Drosophila melanogaster (Fruit fly); NCBI TaxID: 7227;
ModificationList	iodoacetic acid derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-19 10:17:21	ID requested
1	2024-09-09 09:07:54	announced
⏵ 2	2024-10-22 06:57:50	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: embryo,Drosophila, Minibrain

Alexey Veraksa
contact affiliation	University of Massachusetts Boston
contact email	alexey.veraksa@umb.edu
lab head
Alexey Veraksa
contact affiliation	University of Massachusetts Boston
contact email	alexey.veraksa@umb.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/09/PXD052378

PRIDE project URI

• PRIDE
  1. PXD052378
     1. Label: PRIDE project
     2. Name: Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network