PXD052298-1

PXD052298 is an original dataset announced via ProteomeXchange.

Title	A T-cell specific lncRNA LINC01871 is induced upon T cell activation and during beta-cell autoimmunity
Description	Long intergenic noncoding RNAs (lincRNAs) regulate biological processes in health and disease. However, little is known about the contribution of lincRNAs in T-cell activation. Here we found a lincRNA, LINC01871, that is highly induced upon T-cell activation and is primarily located in the cytoplasm. The anti-inflammatory cytokine TGF-β negatively regulates its expression. Its expression is quite specific to different T cell populations among all tissues and cell types. Silencing LINC01871 led to a modest reduction in IL-2 secretion. RNA-seq and proteomic analysis of LINC01871-deficient CD4+ T cells identified its targets, including ATG2B; TRIM5; SNX30; TIMM8B; and ATP10A. Importantly, LINC01871 expression was very specific to T cells in several cross tissue single cell RNA-seq datasets. Further, expression of LINC01871 was higher in ex-vivo CD4+ T cells from children progressing to beta-cell autoimmunity compared to their respective age, sex and HLA-risk matched controls, suggesting that the lincRNA has an in-vivo function in T-cell-mediated immunity. Further, LINC01871 expression was associated with the age, and it was higher in males than females.
HostingRepository	PRIDE
AnnounceDate	2025-08-27
AnnouncementXML	Submission_2025-08-27_03:54:28.060.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kedar Batkulwar
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-16 05:23:02	ID requested
⏵ 1	2025-08-27 03:54:28	announced

Dataset with its publication pending

submitter keyword: LincRNA

T cell activation

IL-2

Type 1 diabetes

Beta-cell autoimmunity

TGF-β

Riitta Lahesmaa
contact affiliation	Molecular Systems Immunology Group Turku Bioscience University of Turku P.O. Box 123, BioCity (Street adr. Tykistökatu 6 A, 7th floor) FIN-20521 Turku, Finland +358-40-718 4813 (Mobile)
contact email	rilahes@utu.fi
lab head
Kedar Batkulwar
contact affiliation	Turku Bioscience, University of Turku, Turku
contact email	kebatk@utu.fi
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD052298
     1. Label: PRIDE project
     2. Name: A T-cell specific lncRNA LINC01871 is induced upon T cell activation and during beta-cell autoimmunity