PXD052284 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | QMP-SO-TMT chemoproteomics to study proteins associate with superoxide biology in HepG2 cells treated with menadione |
| Description | We have developed QMP-SOs, a new class of superoxide-specific probes capable of proximity labelling and chemoproteomic profiling of proteins associated with superoxide redox biology. By coupling QMP-SOs with quantitative proteomics using tandem mass tag, we have established a chemoproteomics platform, QMP-SO-TMT. This enables us to profile proteins associated with superoxide biology in HepG2 cells treated with menadione, which induces mitochondrial superoxide production. |
| HostingRepository | PRIDE |
| AnnounceDate | 2024-08-01 |
| AnnouncementXML | Submission_2024-08-01_04:07:40.721.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Clive Yik-Sham CHUNG |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-16 05:15:21 | ID requested | |
| ⏵ 1 | 2024-08-01 04:07:41 | announced | |
Publication List
Keyword List
| submitter keyword: QMP-SO,Profiling proteins associated with superoxide biology in HepG2 cells treated with menadione through proximity labelling using a superoxide-responsive probe |
Contact List
| Clive Yik-Sham Chung |
|---|
| contact affiliation | Assistant Professor at the School of Biomedical Sciences and Department of Pathology, The University of Hong Kong, Hong Kong |
| contact email | cyschung@hku.hk |
| lab head | |
| Clive Yik-Sham CHUNG |
|---|
| contact affiliation | The University of Hong Kong |
| contact email | cyschung@hku.hk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052284
- Label: PRIDE project
- Name: QMP-SO-TMT chemoproteomics to study proteins associate with superoxide biology in HepG2 cells treated with menadione
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