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PXD052262-1

PXD052262 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleYjbH contributes to S. aureus skin pathology and immune response through Agr-mediated alpha-toxin regulation
DescriptionStaphylococcus aureus is a global health threat that can cause a multitude of diseases in many different areas of the body and is the leading cause of skin infections. This bacterium can produce a variety of proteins that contribute to virulence and disease progression. These virulence factors include alpha-hemolysin (Hla), which can kill many different cell types in the human body. In this study, we identified a new protein that contributes to Hla production, YjbH. It does so by controlling the activity of the Accessory Gene Regulator (Agr), a major player in the modulation of proteins produced in the bacterium. We demonstrate that without YjbH, S. aureus cultures produce less Hla, and this is corroborated during infection. Accordingly, when YjbH is present, tissue damage is greater during infection than when it is absent. Overall, our study sheds light on the complex regulation involved in virulence factor production by S. aureus and its ability to cause a wide range of diseases.
HostingRepositoryMassIVE
AnnounceDate2024-08-26
AnnouncementXMLSubmission_2024-08-26_09:35:27.710.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMichaella Rekowski
SpeciesList scientific name: Staphylococcus aureus subsp. aureus USA300; NCBI TaxID: 367830;
ModificationListOxidation; Carbamidomethyl
InstrumentOrbitrap Ascend
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-14 08:46:03ID requested
12024-08-26 09:35:28announced
Publication List
no publication
Keyword List
submitter keyword: YjbH, alpha-toxin regulatioin
Contact List
Jeffrey L. Bose
contact affiliationUniversity of Kansas Medical Center
contact emailjbose@kumc.edu
lab head
Michaella Rekowski
contact affiliationUniversity of Kansas Medical Center
contact emailmrekowski@kumc.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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