PXD052242-2

PXD052242 is an original dataset announced via ProteomeXchange.

Title	High-fat diet alters retinal lipid composition and gene expression networks in mice
Description	To reveal whether a long-term HFD alters gene expression levels in the retina, we used 4D-label free mass spectrometry to quantify proteins in the whole retinas of HFM and age-mated NM. As the liver plays a crucial role in metabolism of the whole body, HFD has a huge impact on gene expression in the liver. To compare the similarities and differences in the effects of a HFD on retinal and hepatic gene regulatory networks, we also performed proteomic analyses on the livers from HFM and NM.
HostingRepository	iProX
AnnounceDate	2024-05-14
AnnouncementXML	Submission_2025-12-16_01:16:25.079.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rong Zou
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-13 19:56:33	ID requested
1	2025-03-31 19:41:08	announced
⏵ 2	2025-12-16 01:16:26	announced	2025-12-16: Add info.

Zou R, Cai J, Chen T, Mo W, Qian H, Zhu X, Zhang L, High-fat diet alters retinal lipid composition and gene expression networks in mice. BMC Biol, 23(1):103(2025) [pubmed]

submitter keyword: HFD, metabolic homeostasis, retina, cholesterol

Lin Zhang
contact affiliation	University Of Electronic Science And Technology Of China
contact email	zhanglin202@uestc.edu.cn
lab head
Rong Zou
contact affiliation	University Of Electronic Science And Technology Of China
contact email	202121130715@std.uestc.edu.cn
dataset submitter

iProX dataset URI