PXD052194-2

PXD052194 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the liver in hypophysectomy rats
Description	Individuals with hypopituitarism have an increased risk of developing non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) due to growth hormone (GH) deficiency. A rat model of hypopituitarism was established by hypophysectomy, followed by recombinant human growth hormone (rhGH) intervention. The mechanisms underlying GH deficiency-mediated NAFLD were elucidated through the application of label-free proteomics and phosphorylation proteomics.
HostingRepository	iProX
AnnounceDate	2024-05-11
AnnouncementXML	Submission_2024-12-10_19:27:30.267.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuwen Zhang
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	phosphorylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-11 00:19:39	ID requested
1	2024-05-13 18:58:10	announced
⏵ 2	2024-12-10 19:27:31	announced	2024-12-11: Update information.

Zhang Y, Chen P, Fang X, Proteomic and metabolomic analysis of GH deficiency-induced NAFLD in hypopituitarism: insights into oxidative stress. Front Endocrinol (Lausanne), 15():1371444(2024) [pubmed]

submitter keyword: Proteomic, Phosphoproteomics, hypophysectomy rats, GH deficiency, NAFLD

Xuqian Fang
contact affiliation	Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
contact email	251720307@qq.com
lab head
Yuwen Zhang
contact affiliation	Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
contact email	bfzyw@163.com
dataset submitter

iProX dataset URI