PXD052155-1

PXD052155 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mosquito salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission
Description	To identify the putative salivary tPA activator, we fractionated salivary proteins by size-exclusion chromatography and identified fraction Z8 as the strongest tPA activator, whereas the adjacent fractions Z7 and Z9 activated tPA at lower levels. Mass spectrometry analysis of these fractions identified a total of 152 unique proteins.
HostingRepository	PRIDE
AnnounceDate	2025-01-16
AnnouncementXML	Submission_2025-01-16_07:50:13.478.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD052155
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Motoshi Suzuki
SpeciesList	scientific name: Anopheles gambiae (African malaria mosquito); NCBI TaxID: 7165;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-09 16:38:52	ID requested
⏵ 1	2025-01-16 07:50:14	announced

Publication List

10.1038/s41467-024-52502-3;
10.6019/PXD052155;
Pala ZR, Alves E Silva TL, Minai M, Crews B, Patino-Martinez E, Carmona-Rivera C, Valenzuela Leon PC, Martin-Martin I, Flores-Garcia Y, Cachau RE, Muslinkina L, Gittis AG, Srivastava N, Garboczi DN, Alves DA, Kaplan MJ, Fischer E, Calvo E, Vega-Rodriguez J, Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission. Nat Commun, 15(1):8194(2024) [pubmed]

10.1038/s41467-024-52502-3;

10.6019/PXD052155;

Pala ZR, Alves E Silva TL, Minai M, Crews B, Patino-Martinez E, Carmona-Rivera C, Valenzuela Leon PC, Martin-Martin I, Flores-Garcia Y, Cachau RE, Muslinkina L, Gittis AG, Srivastava N, Garboczi DN, Alves DA, Kaplan MJ, Fischer E, Calvo E, Vega-Rodriguez J, Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission. Nat Commun, 15(1):8194(2024) [pubmed]

Keyword List

submitter keyword: Mosquito, Salivary glands, Anopheles gambiae, size-exclusion chromatography

submitter keyword: Mosquito, Salivary glands, Anopheles gambiae, size-exclusion chromatography

Contact List

Joel Vega-Rodriguez
contact affiliation	Chief, Molecular Parasitology and Entomology Unit Laboratory of Malaria and Vector Research National Institutes of Health
contact email	joel.vega-rodriguez@nih.gov
lab head
Motoshi Suzuki
contact affiliation	NIAID
contact email	motoshi.suzuki@nih.gov
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD052155
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/01/PXD052155

PRIDE project URI

Repository Record List

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