PXD052148 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The conserved nuclear poly(A)-binding proteins ZC3H14 and PABPN1 have antagonistic roles in nuclear RNA surveillance |
| Description | Several human diseases have been associated with dysregulated expression of RNA-binding proteins (RBPs). This can be attributed to the wide variety of cellular processes that are controlled by RBPs, including RNA processing, nuclear surveillance, and RNA export. Among RBPs, poly(A)-binding proteins (PABPs) are key players in the 3' end processing and nuclear export of messenger RNAs (mRNAs). Using multidisciplinary approaches, including proteomics and transcriptomics, we aim to investigate the functional relationship between PABPN1 and ZC3H14, in addition to further characterizing the latter. RNA-sequencing shows a set of long noncoding RNAs (lncRNAs) that are antagonistically regulated by ZC3H14 and PABPN1. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-28 |
| AnnouncementXML | Submission_2026-08-28_13:34:15.029.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | François Bachand |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | biotinylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-09 12:32:33 | ID requested | |
| ⏵ 1 | 2026-08-28 13:34:15 | announced | |
Publication List
Keyword List
| submitter keyword: Human, Polyadenylation, PAXT, PABP, RNA decay, LC-MS/MS |
Contact List
| François Bachand |
|---|
| contact affiliation | Department of biochemistry and functional genomics, University of Sherbrooke. Qc,Canada |
| contact email | francois.bachand2@usherbrooke.ca |
| lab head | |
| François Bachand |
|---|
| contact affiliation | University of Sherbrooke |
| contact email | bachandlabo@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD052148 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052148
- Label: PRIDE project
- Name: The conserved nuclear poly(A)-binding proteins ZC3H14 and PABPN1 have antagonistic roles in nuclear RNA surveillance
