PXD052130-1

PXD052130 is an original dataset announced via ProteomeXchange.

Title	A proteomics-based exploration of the neuroprotective mechanism of Semaglutide in acute ischemic stroke mice
Description	Glucagon-like Peptide-1 receptor agonists (GLP-1RA) are gaining increasing momentum as possible neuroprotective agents in acute ischemic stroke. In this study, we investigate the neuroprotective effects of a novel GLP-1RA, Semaglutide, in the treatment of acute ischemic stroke and their underlying mechanisms. The current study first mapped comprehensive proteomic changes after acute ischemic stroke treated with Semaglutide, providing a foundation for developing potentially therapeutic targets for anti-acute ischemic stroke and clinically prognostic biomarkers of stroke.
HostingRepository	iProX
AnnounceDate	2024-05-08
AnnouncementXML	Submission_2024-05-08_22:30:31.130.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wanzhou Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-08 22:30:01	ID requested
⏵ 1	2024-05-08 22:30:31	announced

Dataset with its publication pending

submitter keyword: ischemic stroke, Semaglutide, Proteomics, Glycolysis, ferroptosis

Li Ling
contact affiliation	Department of Neurology, Shenzhen Hospital, Southern Medical University, China
contact email	linglirabbit@163.com
lab head
Wanzhou Zhang
contact affiliation	Department of Neurology, Shenzhen Hospital, Southern Medical University, China
contact email	zhangwanzhou2021@qq.com
dataset submitter

iProX dataset URI