PXD052123-1

PXD052123 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The cargos and roles of small extracellular vesicles from cochlear explants in cisplatin-induced ototoxicity
Description	Small extracellular vesicles (sEVs) play an important role in intercellular communication as well as pathological development. Here, to explore the roles of sEVs in the progression of cisplatin-induced ototoxicity, we isolated sEVs from the conditioned culture medium of cisplatin-induced cochlear explants (Cis-sEVs) and the control group (Ctrl-sEVs) and profiled their cargos using label-free LC-MS/MS. Numerous proteins involved in the regulation of the damage response were enriched in the Cis-sEVs. Cltc, Cct2, and Hspa8, which are potentially involved in protein homeostasis and autophagy, are up-regulated in Cis-sEVs compared to Ctrl-sEVs but not in cisplatin-damaged cochlear tissue or in HEI-OC1 cell lysates.
HostingRepository	PRIDE
AnnounceDate	2025-09-01
AnnouncementXML	Submission_2025-08-31_16:14:11.750.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jingru Ai
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-08 19:25:30	ID requested
⏵ 1	2025-08-31 16:14:12	announced

Publication List

10.1002/advs.202502627;
Ai J, Zhang S, Dai M, Jiang P, Huang J, Xiao H, Lin Y, Tang X, Tong W, He J, Mao Q, Wang Y, Ye Z, Wang T, Chai R, Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery. Adv Sci (Weinh), 12(30):e02627(2025) [pubmed]

10.1002/advs.202502627;

Ai J, Zhang S, Dai M, Jiang P, Huang J, Xiao H, Lin Y, Tang X, Tong W, He J, Mao Q, Wang Y, Ye Z, Wang T, Chai R, Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery. Adv Sci (Weinh), 12(30):e02627(2025) [pubmed]

Keyword List

submitter keyword: Cisplatin-induced ototoxicity, sEV, Cltc, Hspa8, biomarkers, Cct2

submitter keyword: Cisplatin-induced ototoxicity, sEV, Cltc, Hspa8, biomarkers, Cct2

Contact List

Renjie Chai
contact affiliation	1State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China.2 Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China.
contact email	renjiec@seu.edu.cn
lab head
Jingru Ai
contact affiliation	southeast university
contact email	aijr314@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD052123
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD052123

PRIDE project URI

Repository Record List

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