PXD052078-1

PXD052078 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Hypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells
Description	• Exposure of endothelial cells (HCAECs) to hypoxia alters gene an protein expression • Genes and proteins related to endothelial dysfunction and activation are overexpressed • Hypoxia induces a versican-rich matrix with an altered glycosaminoglycan profile • This modified matrix perturbs cell adhesion but enhances proliferation and hyaluronan binding • Hypoxia upregulates oxidant formation and proteins related to inflammation
HostingRepository	PRIDE
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-24_16:46:26.023.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lasse Gøbel Lorentzen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-07 08:12:08	ID requested
⏵ 1	2025-08-24 16:46:26	announced

Publication List

10.1016/j.jbc.2025.110459;
J, ø, rgensen SM, Huang S, Lorentzen LG, Teoh FKY, Karlsson R, Harkness JR, Miller RL, Davies MJ, Chuang CY, Hypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells. J Biol Chem, 301(8):110459(2025) [pubmed]

10.1016/j.jbc.2025.110459;

J, ø, rgensen SM, Huang S, Lorentzen LG, Teoh FKY, Karlsson R, Harkness JR, Miller RL, Davies MJ, Chuang CY, Hypoxia promotes the generation of a versican-rich extracellular matrix by human coronary artery endothelial cells. J Biol Chem, 301(8):110459(2025) [pubmed]

Keyword List

submitter keyword: ECM,Hypoxia, Proteomics

submitter keyword: ECM,Hypoxia, Proteomics

Contact List

Michael Davies
contact affiliation	BMI, University of Copenhagen, Denmark
contact email	davies@sund.ku.dk
lab head
Lasse Gøbel Lorentzen
contact affiliation	University of Copenhagen
contact email	lassegl@sund.ku.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD052078
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD052078

PRIDE project URI

Repository Record List

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