PXD052076 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing. |
Description | Single cell sequencing in peripheral blood mononuclear cells (PBMCs) revealed a novel human-specific long noncoding RNA called heart-failure associated transcript 4 (HEAT4). HEAT4 expression was assessed in several in vitro and ex vivo models of immune cell activation, as well as in the blood of patients with heart failure (HF), acute myocardial infarction (AMI) and cardiogenic shock (CS). The transcriptional regulation of HEAT4 was verified through cytokine treatment and single cell sequencing. Loss-of-function and gain-of-function studies and multiple RNA–protein interaction assays uncovered a mechanistic role of HEAT4 in the monocyte anti-inflammatory gene program. HEAT4 expression and function was characterized in a vascular injury model in NOD.CB-17-Prkdc scid/Rj mice. |
HostingRepository | PRIDE |
AnnounceDate | 2024-08-14 |
AnnouncementXML | Submission_2024-08-14_07:54:07.213.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ann-Christine König |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2024-05-07 07:22:34 | ID requested | |
⏵ 1 | 2024-08-14 07:54:07 | announced | |
2 | 2024-10-22 06:55:05 | announced | 2024-10-22: Updated project metadata. |
Publication List
Keyword List
submitter keyword: Monocytes, Long non-coding RNA,Heart Failure, Vascular regeneration |
Contact List
Jes-Niels Boeckel |
contact affiliation | Universitätsklinikum Leipzig, Klinik und Poliklinik für Kardiologie, Leipzig, Germany |
contact email | jes-niels.boeckel@medizin.uni-leipzig.de |
lab head | |
Ann-Christine König |
contact affiliation | HMGU Core Facility Proteomics |
contact email | ann-christine.koenig@helmholtz-muenchen.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD052076 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD052076
- Label: PRIDE project
- Name: Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing.