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PXD052041-1

PXD052041 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleATPase activity of RIOK2 transports FADD–RIPK1–Caspase-8 complex from lysosome to ER and triggers spatial cleavage of GSDMD
DescriptionWe identified RIOK2 as a FADD-interacting protein that is essential for caspase-8-dependent cleavage of GSDMD. RIOK2’s ATPase activity drives the transport of lysosome to ER through activating myosin II and thereby translocate FADD-RIPK1-caspase-8 complex from lysosome to ER. Importantly, RIOK2’s ATPase activity also promotes the association of RIOK2 with FADD–RIPK1–caspase-8 complex and directly activates cleavage of caspase-8 and GSDMD both at ER and in vitro.
HostingRepositoryiProX
AnnounceDate2024-05-07
AnnouncementXMLSubmission_2024-05-06_20:47:46.038.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMingtong Ma
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-06 20:47:16ID requested
⏵ 12024-05-06 20:47:46announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: ATPase, RIOK2, translocation, ER
Contact List
Baoxue Ge
contact affiliationTongji University
contact emailbaoxue_ge@tongji.edu.cn
lab head
Mingtong Ma
contact affiliationTongji University
contact emailmingtongma@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI

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