PXD051984 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Functional Heterogeneity Analysis of Mesenchymal Stem Cell Lines and their Therapeutic Potential in the K18-hACE2 Mouse Model of SARS-CoV-2 Infection |
| Description | Despite many years of investigation into mesenchymal stem cells (MSCs) and their potential for treating inflammatory conditions such as COVID-19, clinical outcomes remain variable due to factors like donor variability, different tissue sources, and diversity within MSC populations. Variations in MSCs' secretory and proliferation profiles, and their proteomic and transcriptional characteristics significantly influence their therapeutic potency, highlighting the need for standardized and enhanced characterization methods to better predict their efficacy. This study aimed to evaluate the biological characteristics and therapeutic efficacy of MSCs from different tissue origins, selecting the most promising line for further validation in a K18-hACE2 mouse model of SARS-CoV-2 infection. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-05-07 |
| AnnouncementXML | Submission_2025-05-06_16:07:42.877.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gisele Rocha |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-05-04 08:31:40 | ID requested | |
| ⏵ 1 | 2025-05-06 16:07:43 | announced | |
Publication List
| 10.1186/s13287-024-04086-4; |
| da Silva KN, Marim FM, Rocha GV, Costa-Ferro ZSM, Fran, ç, a LSA, Nonaka CKV, Paredes BD, Rossi EA, Loiola EC, Adanho CSA, Cunha RS, Silva MMAD, Cruz FF, Costa VV, Zanette DL, Rocha CAG, Aguiar RS, Rocco PRM, Souza BSF, Functional heterogeneity of mesenchymal stem cells and their therapeutic potential in the K18-hACE2 mouse model of SARS-CoV-2 infection. Stem Cell Res Ther, 16(1):15(2025) [pubmed] |
Keyword List
| submitter keyword: COVID-19 |
| K18-hACE2, immunomodulation,mesenchymal stem cells |
| heterogeneity |
Contact List
| Bruno Solano de Freitas Souza |
|---|
| contact affiliation | Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Brazil Center for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil D'Or Institute for Research and Education (IDOR), Salvador, Brazil |
| contact email | bruno.solano@fiocruz.br |
| lab head | |
| Gisele Rocha |
|---|
| contact affiliation | D'Or Institute for Research and Education (IDOR)
Gonçalo Moniz Institute, FIOCRUZ |
| contact email | givieiraroch@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051984
- Label: PRIDE project
- Name: Functional Heterogeneity Analysis of Mesenchymal Stem Cell Lines and their Therapeutic Potential in the K18-hACE2 Mouse Model of SARS-CoV-2 Infection
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