PXD051945-1

PXD051945 is an original dataset announced via ProteomeXchange.

Title	Deficiency of Antioxidant Enzyme PRDX6 and Mucosal Chemokine CXCL17: Unraveling the Factors Behind Oxidative Stress and Mucosal Homeostasis Disruption in Dry Eye Disease
Description	This study aimed to identify dysregulated proteins, signaling pathways, and biological processes on the ocular surface of patients with Sjögren’s syndrome dry eye (SSDE) disease. Non-targeted proteomic analysis of Schirmer strip (ScS) samples from 12 SSDE patients compared to 6 healthy subjects (HS) revealed 111 dysregulated proteins. It showed significant proteome segregation between SSDE patients and HS, revealing alterations in the cytoskeleton, cell junctions, and cellular metabolism, as well as increased apoptosis and oxidative stress and reduced levels of CXCL17 and PRDX6 in SSDE.
HostingRepository	PRIDE
AnnounceDate	2025-07-25
AnnouncementXML	Submission_2025-07-25_05:40:13.361.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD051945
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Cédric Pionneau
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-05-02 07:55:52	ID requested
⏵ 1	2025-07-25 05:40:13	announced

10.6019/PXD051945;

10.1016/J.BBADIS.2025.167911;

submitter keyword: Tear film, Signaling pathways, CXCL17, PRDX6, Cytoskeleton, Biomarker,Dry eye disease, Sjögren’s syndrome, timsTOF Pro, LC-MS/MS

Karima KESSAL
contact affiliation	Institut National de la Santé et de la Recherche Médicale INSERM UMRS 968, CNRS UMR 7210, Institut de la Vision, IHU ForeSight, Sorbonne Université UM80, 75012 Paris, France
contact email	karima.kessal@inserm.fr
lab head
Cédric Pionneau
contact affiliation	Plateforme P3S UMS-37 PASS – Sorbonne Universite
contact email	cedric.pionneau@sorbonne-universite.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD051945

PRIDE project URI

• PRIDE
  1. PXD051945
     1. Label: PRIDE project
     2. Name: Deficiency of Antioxidant Enzyme PRDX6 and Mucosal Chemokine CXCL17: Unraveling the Factors Behind Oxidative Stress and Mucosal Homeostasis Disruption in Dry Eye Disease