PXD051880-1

PXD051880 is an original dataset announced via ProteomeXchange.

Title	Immunopeptidome of Human Renal Cell Carcinoma (RCC) derived cells infected with oncolytic viruses.
Description	In this study we demonstrate the effect of oncolytic adenoviruses armed with CXCL9, CXCL10 and IL-15 to infect cancer cells, secrete the encoded protein and drive gradient-dependent T-cell attraction. Our in vivo validation demonstrated an increased intratumoral CD4+ and CD8+ T-cell infiltration following treatment with armed viruses compared to control groups. Finally, RCC cells were screened for tumor-specific peptides to validate their immunogenicity in a (personalized) oncolytic cancer vaccine approach, previously referred to as PeptiCRAd.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_15:04:05.071.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rui Branca
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	timsTOF SCP

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-30 03:00:31	ID requested
⏵ 1	2025-05-06 15:04:05	announced

Feodoroff M, Hamdan F, Antignani G, Feola S, Fusciello M, Russo S, Chiaro J, V, ä, lim, ä, ki K, Pellinen T, Branca RM, Lehti, ö J, D Alessio F, Bottega P, Stigzelius V, Sandberg J, Clancy J, Partanen J, Malmstedt M, Rannikko A, Pieti, ä, inen V, Gr, ö, nholm M, Cerullo V, Enhancing T-cell recruitment in renal cell carcinoma with cytokine-armed adenoviruses. Oncoimmunology, 13(1):2407532(2024) [pubmed]

10.1080/2162402x.2024.2407532;

submitter keyword: oncolytic adenovirus, Human, PeptiCRAd,Ligandome, Immunopeptidome, HLA-I, MHC-I, RCC, IL-15, CXCL10, CXCL9

Janne Lehtiö
contact affiliation	Dept. Oncology-Pathology, Scilifelab, Karolinska Institutet, Sweden
contact email	janne.lehtio@ki.se
lab head
Rui Branca
contact affiliation	Clinical Proteomics Unit, Dep. of Oncology-Pathology
contact email	rui.mamede-branca@ki.se
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD051880

PRIDE project URI

• PRIDE
  1. PXD051880
     1. Label: PRIDE project
     2. Name: Immunopeptidome of Human Renal Cell Carcinoma (RCC) derived cells infected with oncolytic viruses.