PXD051806-1
PXD051806 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Colonic transcriptomic and proteomic profiling provides new insight into the pathogenesis of chronic colitis in interleukin-10-deficient mice |
| Description | Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune disease of gastrointestinal tract (GI), involving in dysfunction of a variety of genes, such as Interleukin (IL)-10. Intense researches have demonstrated that IL10-deficient (IL10-/-) mice gradually exhibits features of spontaneous enterocolitis at 4-8 weeks of age and IL-10 is a significant immunomodulator in intestinal tract. Therefore, IL10-/- mice have become a classic model of enterocolitis to study the pathogenesis of IBD. The prevailing view is that IL10 deficiency leads to abnormal activation of immune cells and overproduction of a range of inflammation-inducing cytokines, which results in the persistence of intestinal inflammation in the mice. To uncover the role of the underlying molecular mechanisms involved in IL10-/--associated chronic enterocolitis, we construct IL10-deficient mice, sequence transcriptome and proteome of colon tissues from the mice with colitis and perform an integrated analysis of the two omics in this study. Mechanically, we might find out several novel signaling pathways or new therapeutic targets for IBD according to this combined analysis. |
| HostingRepository | iProX |
| AnnounceDate | 2024-04-26 |
| AnnouncementXML | Submission_2025-05-05_22:07:17.848.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lili Li |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-27 19:58:42 | ID requested | |
| ⏵ 1 | 2025-05-05 22:07:18 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: interleukin-10-deficient mice,chronic colitis,inflammatory bowel disease，LC-MSMS |
Contact List
| Hu Zhang | |
|---|---|
| contact affiliation | West China Hospital, Sichuan University |
| contact email | wilderness202401@163.com |
| lab head | |
| Lili Li | |
| contact affiliation | West China Hospital, Sichuan University |
| contact email | michellele1124@hotmail.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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