PXD051695-1

PXD051695 is an original dataset announced via ProteomeXchange.

Title	A phosphatase-like nanomaterial promotes autophagy and reprograms macrophage for cancer immunotherapy
Description	Macrophages are very plastic and play key roles in maintenance of tissue homeostasis. In cancer progression, macrophages also take parts through all the processes, from the initiation, progression, to the final tumor metastasis. Although energy deprivation and autophagy are widely used for cancer therapy, most of these strategies are not meant to target macrophages resulting in undesired effects and unsatisfactory outcomes for cancer immunotherapy. Herein, we developed a lanthanum nickel oxide (LNO) nanozyme that possesses phosphatase-like activity for ATP hydrolysis. Meanwhile, the autophagy of macrophages induced by LNO promotes the polarization of macrophages from M2-like macrophage (M2) to M1-like macrophage (M1) and reduces tumor-associated macrophages in tumor-bearing mice, exhibiting capability of killing tumor-associated macrophage and anti-tumor effect in vivo. Furthermore, pre-coating by myeloid cell membrane on the surface of LNO significantly enhanced antitumor immunity. Our findings demonstrate that phosphatase-like nanozyme, LNO can specifically induce macrophage autophagy that improves therapeutic efficacy and offers valuable strategies for cancer immunotherapy.
HostingRepository	PRIDE
AnnounceDate	2024-08-10
AnnouncementXML	Submission_2024-08-10_15:59:25.954.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Liming Wang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	carbamoylated residue; acetylated residue; monohydroxylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-24 02:46:10	ID requested
⏵ 1	2024-08-10 15:59:26	announced

10.1039/d4sc01690d;

Baimanov D, Li S, Gao XJ, Cai R, Liu K, Li J, Liu Y, Cong Y, Wang X, Liu F, Li Q, Zhang G, Wei H, Wang J, Chen C, Gao X, Li Y, Wang L, A phosphatase-like nanomaterial promotes autophagy and reprograms macrophages for cancer immunotherapy. Chem Sci, 15(28):10838-10850(2024) [pubmed]

submitter keyword: RAW264.7,mice, phospho-proteins, LC-MS/MS

Liming Wang
contact affiliation	Institute of High Energy Physics, CAS
contact email	wangliming@ihep.ac.cn
lab head
Liming Wang
contact affiliation	Institute of High Energy Physics, Chinese Academy of Sciences
contact email	wangliming@ihep.ac.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD051695

PRIDE project URI

• PRIDE
  1. PXD051695
     1. Label: PRIDE project
     2. Name: A phosphatase-like nanomaterial promotes autophagy and reprograms macrophage for cancer immunotherapy