PXD051668-1

PXD051668 is an original dataset announced via ProteomeXchange.

Title	SILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells
Description	Ketogenesis derived BHB facilitates 3-hydroxybutyrylation on lysine linking metabolism with epigenetic regulation. Herein, we found HBO1 served as 3-hydroxybutyryltransferase preferentially catalyzing lysine 9 of histone H3 (H3K9bhb). Moreover, total 1171 Kbhb sites on 582 proteins were identified. Collectively, we firstly descibed HBO1 mediated Kbhb regulatory network in HeLa cells.
HostingRepository	PRIDE
AnnounceDate	2025-07-04
AnnouncementXML	Submission_2025-07-04_06:37:34.950.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	siyu wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	carbamoylated residue; 6x(13)C labeled residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-23 08:10:13	ID requested
⏵ 1	2025-07-04 06:37:35	announced

Dataset with its publication pending

submitter keyword: Human, cervical cancer, Kbhb, HBO1, LC-MS/MS

Kai Zhang
contact affiliation	Tianjin Medical University
contact email	kzhang@tmu.edu.cn
lab head
siyu wang
contact affiliation	TianJin Medical University
contact email	13753216903@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD051668

PRIDE project URI

• PRIDE
  1. PXD051668
     1. Label: PRIDE project
     2. Name: SILAC based quantitative 3-hydroxybutyromics of HBO1-WT and HBO1-KO HeLa cells