PXD051618-1
PXD051618 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Label-free quantitative data dependent (DDA) nano-LC-MS/MS proteomic profiling of mouse lymph harvested from mesenteric and cervical anatomical districts |
| Description | To fully quantify differences in the lymph composition and associated dendritic cells antigenic load, from different anatomical districts and in physiological and pathological conditions, we collected the afferent lymph draining to the cervical and mesenteric lymph nodes in healthy mice. Most of the proteome present in the mesenteric afferent lymph, showed a profile of proteins involved in different metabolic pathways associated with lipoproteintransport, and lipid metabolism, such as adipocyte-type fatty acid binding protein, Apolipoproteins A, B, C and E, and phospholipid transfer proteins, consistent with the known role of the mesenteric lymph in chylomicron transport. Network analysis on the mesenteric afferent lymph unique/enriched proteome highlighted pathways associated with lipase and hydrolase activity, lipoproteins remodeling, fat digestion and absorption, triglyceride catabolism and gut-associated immune cells and cytokines responses. Among the proteome shared across tissue a brain-specific or highly enriched proteome including glia maturation factor, nerve growth factor, mesencephalic astrocyte-derived neurotrophic factor, alpha-crystallin, brain-specific isoform of glycogen phosphorylase, and proteins associated with voltage-dependent channels, were uniquely observed in the lymph harvested from the afferent lymphatics entering the deep cervical nodes. Network analysis on the afferent cervical unique/enriched proteome highlighted pathways associated with neurotransmitter release cycle, synaptic transmission, neuronal development, mitochondrial activity, and an overall CNS proteome. |
| HostingRepository | MassIVE |
| AnnounceDate | 2024-04-21 |
| AnnouncementXML | Submission_2024-04-21_18:00:19.063.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Cristina C Clement |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide; Gln->pyro-Glu; Glu->pyro-Glu |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-04-21 17:21:08 | ID requested | |
| ⏵ 1 | 2024-04-21 18:00:19 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: mouse, mesenteric and cervical lymph, label free quantitative proteomics profiling on QEHF mass spectrometer |
Contact List
| Laura Santambrogio | |
|---|---|
| contact affiliation | Weill Cornell Medicine College |
| contact email | las4011@med.cornell.edu |
| lab head | |
| Cristina C Clement | |
| contact affiliation | Weill Cornell Medicine College |
| contact email | ccc4002@med.cornell.edu |
| lab head | |
| Cristina C Clement | |
| contact affiliation | Weill Cornell Medicine |
| contact email | ccc4002@med.cornell.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094586/ |
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