PXD051544-1

PXD051544 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cold Atmospheric Plasma Jet Promotes Wound Healing through CK2- coordinated PI3K/AKT and MAPK Signaling Pathways
Description	Cold atmospheric plasma jet (CAPJ) is composed of a variety of reactive species and has been demonstrated to have an effect on promoting wound healing. However, not all served-subjects respond equally to CAPJ, and indeed the underlying cellular mechanisms are rarely understood. Proteomics results clearly revealed that wound repair in keratinocytes was accelerated by plasma-activated medium (PAM) treatment through phosphorylating CK2-coordinated PI3K/AKT and MAPK signaling pathways, activating their downstream physiological responses for cell migration, proliferation and extracellular vesicles mediated cell-cell communication. Moreover, CAPJ-treated wound tissues showed a denser and well-organized extracellular matrix (ECM) architecture, implying the speed-up of epithelialization in wound healing. This study unveiled the primary cellular responses affected by CAPJ during wound repair, providing valuable insights for the treatment selection and the development of therapeutic strategies to achieve better therapy outcomes.
HostingRepository	jPOST
AnnounceDate	2025-04-17
AnnouncementXML	Submission_2025-04-16_08:00:14.830.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Miao-Hsia Lin
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; alpha-amino acetylated residue; L-methionine sulfoxide
Instrument	instrument

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-18 00:17:55	ID requested
⏵ 1	2025-04-16 08:00:15	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: cold atmospheric plasma jet (CAPJ), keratinocyte, plasma activated medium (PAM), wound healing, (phospho)proteomics, PI3K/AKT signaling, MAPK signaling, CK2 kinase

submitter keyword: cold atmospheric plasma jet (CAPJ), keratinocyte, plasma activated medium (PAM), wound healing, (phospho)proteomics, PI3K/AKT signaling, MAPK signaling, CK2 kinase

Contact List

Miao-Hsia Lin
lab head
Miao-Hsia Lin
contact affiliation	Department of Microbiology, College of Medicine, National Taiwan University
dataset submitter

Full Dataset Link List

jPOST dataset URI
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jPOST dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003041/