PXD051537 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina |
| Description | Inherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of photoreceptors, which ultimately lead to blindness. Among the causes of this condition, mutations in the PCYT1A gene, which encodes the rate-limiting enzyme responsible for phosphatidylcholine (PC) de novo synthesis via the Kennedy pathway, have been identified. However, the precise mechanisms underlying the association between PCYT1A mutations and IRDs remain unclear. To address this knowledge gap, we focused on elucidating the functions of PCYT1A in the retina. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-06-09 |
| AnnouncementXML | Submission_2025-06-08_16:08:19.927.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | kaifang wang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2024-04-17 22:19:30 | ID requested | |
| ⏵ 1 | 2025-06-08 16:08:20 | announced | |
Publication List
| Wang K, Xu H, Zou R, Zeng G, Yuan Y, Zhu X, Zhao X, Li J, Zhang L, PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina. BMC Biol, 22(1):134(2024) [pubmed] |
| 10.1186/s12915-024-01932-y; |
Keyword List
| submitter keyword: IRDs |
| PCYT1A |
| Fatty acid metabolism |
| Ferroptosis |
Contact List
| kaifang wang |
|---|
| contact affiliation | University of Electronic Science and Technology of China |
| contact email | kaifang_wang@126.com |
| lab head | |
| kaifang wang |
|---|
| contact affiliation | University of Electronic Science and Technology of China |
| contact email | kaifang_wang@126.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/06/PXD051537 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD051537
- Label: PRIDE project
- Name: PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
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