PXD051517-1

PXD051517 is an original dataset announced via ProteomeXchange.

Title	Bone Morphogenetic Protein 9 Protects against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics
Description	We investigated the impact of both BMP9 deficiency and replenishment on the pathogenesis of MI in mice. Our results showed an aggravated pathological phenotype of MI in BMP9 knockout (KO) mice, which can be alleviated by replenishment of BMP9. Therefore, we further investigated the mechanism whereby BMP9 protects against MI-induced cardiac damage and dysfunction via its multiple actions among the liver, lymph, and heart.
HostingRepository	iProX
AnnounceDate	2024-04-17
AnnouncementXML	Submission_2024-12-08_20:13:22.552.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zikun Duan
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-16 23:12:46	ID requested
⏵ 1	2024-12-08 20:13:23	announced

Duan Z, Huang Z, Lei W, Zhang K, Xie W, Jin H, Wu M, Wang N, Li X, Xu A, Zhou H, Wu F, Li Y, Lin Z, Bone Morphogenetic Protein 9 Protects Against Myocardial Infarction by Improving Lymphatic Drainage Function and Triggering DECR1-Mediated Mitochondrial Bioenergetics. Circulation, 150(21):1684-1701(2024) [pubmed]

submitter keyword: Myocardial infarction, BMP9, DECR1, Mitochondrial bioenergetics, Lymphatic drainage dysfunction

Zhuofeng Lin
contact affiliation	Dongguan Songshan Lake Center Hospital affiliated to Guangdong Medical University
contact email	zhuofenglin@wmu.edu.cn
lab head
Zikun Duan
contact affiliation	Dongguan Songshan Lake Center Hospital affiliated to Guangdong Medical University
contact email	dzk880909@163.com
dataset submitter

iProX dataset URI