PXD051500-1

PXD051500 is an original dataset announced via ProteomeXchange.

Title	Proteomics of 58 platinum-sensitive and 30 platinum-resistant ovarian cancer tissue-derived exosomes
Description	In this study, 4D data-independent acquisition (DIA) proteomic sequencing was performed on exosomes obtained from 58 platinum-sensitive and 30 platinum-resistant patients with EOC. The analysis revealed a notable enrichment of differentially expressed proteins that were predominantly associated with immune-related pathways. Moreover, pivotal immune-related proteins (IRPs) were identified by LASSO regression. These factors, combined with clinical parameters selected through univariate logistic regression, were used for the construction of a model employing multivariate logistic regression.
HostingRepository	PRIDE
AnnounceDate	2024-10-17
AnnouncementXML	Submission_2024-10-17_06:07:03.927.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shizhen Shen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	autoflex

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-16 12:11:03	ID requested
⏵ 1	2024-10-17 06:07:04	announced

Shen S, Wang C, Gu J, Song F, Wu X, Qian F, Chen X, Wang L, Peng Q, Xing Z, Gu L, Wang F, Cheng X, A Predictive Model for Initial Platinum-Based Chemotherapy Efficacy in Patients with Postoperative Epithelial Ovarian Cancer Using Tissue-Derived Small Extracellular Vesicles. J Extracell Vesicles, 13(8):e12486(2024) [pubmed]

10.1002/jev2.12486;

submitter keyword: Human, Ovarian cancer, tissue-derived exosomes, 4D DIA proteomics

Shizhen Shen
contact affiliation	Zhejiang University, Hangzhou 310006 Zhejiang, ChinaChina
contact email	21818414@zju.edu.cn
lab head
Shizhen Shen
contact affiliation	Zhejiang University
contact email	21818414@zju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/10/PXD051500

PRIDE project URI

• PRIDE
  1. PXD051500
     1. Label: PRIDE project
     2. Name: Proteomics of 58 platinum-sensitive and 30 platinum-resistant ovarian cancer tissue-derived exosomes